Understanding Immunology - Peter Wood - 9780273730682 - Prentice Hall - Pearson Schweiz AG - Der Fachverlag fuer Bildungsmedien - 978-0-2737-3068-2

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Understanding Immunology

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Titel:   Understanding Immunology
Reihe:   Prentice Hall
Autor:   Peter Wood
Verlag:   Prentice Hall
Einband:   Softcover
Auflage:   3
Sprache:   Englisch
Seiten:   352
Erschienen:   März 2011
ISBN13:   9780273730682
ISBN10:   0-27373-068-1
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Understanding Immunology

Description

Understanding Immunology is a well-established introduction to this complex subject for readers with no previous exposure. It is aimed primarily at undergraduates in biological sciences, biomedical sciences and medicine. The selection and order of topic coverage is designed to instruct effectively, and a variety of boxed examples add depth and historical context for those readers wanting to go beyond the essentials.

 


New to this Edition

This third edition is revised to cover the latest experimental and clinical changes in the subject, particularly those in the development of lymphocytes; the different types of CD4 helper T cells; the use of antibodies, including monoclonal antibodies, as experimental and clinical tools; and immunological tolerance.

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Table of Contents

Contents

 

Preface                                                                                                                        

Acknowledgements                                                                                                     

 

1    The threat to the body: the role and requirements of the immune system      

1.1    The role and complexity of the immune system                                               

1.2    Pathogens differ in size, lifestyle and how they cause disease                          

1.3    How do pathogens cause disease and what protection is there?                     

1.4    Conclusion                                                                                                   

1.5    Summary                                                                                                      

1.6    Questions and answers                                                                                 

1.7    Further reading                                                                                             

 

2    The immediate response to infection: innate immunity and the
inflammatory response                                                                                       

2.1    The response to infection                                                                              

2.2    The immediate response to infection – the innate immune system

2.3    Cytokines – hormones of the immune system                                                 

2.4    The inflammatory response and cell migration                                                

2.5    Cell migration – through blood and into tissue                                                

2.6    The inflammatory response                                                                            

2.7    Systematic inflammation – involvement of the brain and liver                           

2.8    Opsonins cans                                                             

2.9    Interferons and natural killer cells                                                                   

2.10  The innate immune response limits the early replication of pathogens               

2.11  Summary                                                                                                      

2.12  Questions and answers                                                                                  

2.13  Further reading                                                                                              

 

3    Specific immune recognition: B lymphocytes and the antibody molecule        

3.1    Introduction to the specific immune system                                                    

3.2    Antibody structure                                                                                        

3.3    Recognition by antibody – antigens and epitopes                                              

3.4    There are different antibody classes with different biological functions             

3.5    Antibody can be secreted or expressed on the cell surface of B lymphocytes

3.6    Summary                                                                                                      

3.7    Questions and answers                                                                                 

3.8    Further reading

 

4    T lymphocytes and MHC-associated recognition of antigen                           

4.1    There are different types of T lymphocytes                                                    

4.2    T cells recognise antigen through their T cell receptor (TCR)

4.3    The major histocompatibility complex                                                            

4.4    Recognition of antigen by T cells                                                                   

4.5    Antigens must be processed before they can be presented by MHC molecules           

4.6    Summary                                                                ;                                     

4.7    Questions and answers                                                                                 

4.8    Further reading

 

5    Lymphocyte development and the generation of antigen receptors                

5.1    The production of lymphocytes: lymphopoiesis                                              

5.2    B lymphocytes are produced in the bone marrow                                          

5.3    T lymphocytes finish their production in the thymus                                        

5.4    During their development lymphocytes must generate huge numbers of Ig and TCR receptors with different antigen specificities                                       

5.5    Developing lymphocytes rearrange their lg or TCR genes in a carefully controlled order                                                                              

5.6    Why is there continuous production of lymphocytes, most of which die?

5.7    Summary                                                                                                      

5.8    Questions and answers                                                                                 

5.9    Further reading

 

6    Anatomy of the immune system                                                                         

6.1    Requirements of the immune system in vivo                                                  

6.2    Different pathogens require different types of immune responses                     

6.3    The anatomy of the lymphoid system promotes the interaction of cells and antigen      

6.4    Lymphocytes continually recirculate through blood, tissues and lymphatic vessels         

6.5    Summary                                                                                                      

6.6    Questions and answers                                                                                 

6.7    Further reading

 

7    Anatomical and cellular aspects of antibody production                                   

7.1    Overview of antibody production                                                                  

7.2    Activation of CD4 T cells (0–5 days)                                   &                        

7.3    Stimulation of B cells by antigen and their interaction with Th (0–5 days after antigen) 

7.4    Formation of germinal centres (4–14 days after antigen)                                 

7.5    MALT and the production of IgA                                                                 

7.6    Summary                                                                                                      

7.7    Questions and answers                                                                                 

7.8    Further reading

 

8    Effector mechanisms: dealing with pathogens in vivo (1)  Antibody-mediated responses                               

8.1    Humoral and cell-mediated immunity                                                             

8.2    Antibodies provide protection in many different ways                                     

8.3    Neutralisation by antibody                                                                             

8.4    Antibodies can cause agglutination of microbes                                              

8.5    Antibodies can act as opsonins and promote phagocytosis                             

8.6    Complement is a protein cascade with antimicrobial functions                          

8.7    Antibody and complement synergise to promote the opsonisation of microbes

8.8    Antibody-dependent cell-mediated cytoxicity (ADCC)                                  

8.9    Summary                                                                                                      

8.10  Questions and answers                                                                                 

8.11  Further reading                                                                                             

 

9    Effector mechanisms: dealing with pathogens in vivo (2) Cell-mediated immunity     

9.1    Introduction

9.2    CD4 T cells develop into different types of helper T cells                               

9.3    CD8 cytotoxic T cells are important in intracellular infections                          

9.4    Delayed-type hypersensitivity and the activation of macrophages                    

9.5    Th2 responses are important against worms                         p;                        

9.6    Th17 responses involve high levels of inflammation                                                  

9.7    Different effector responses have different costs to the host                            

9.8    Summary                                                                                                      

9.9    Questions and answers                                                                                 

9.10  Further reading                                                                                            

 

10  Immunological memory and vaccination, the production and use of antibodies          

10.1  Immunological memory – the basis of immaturity                                            

10.2  Vaccines induce immunity without causing disease                                                                                                                                          

10.3  Antibodies can be produced and used in many ways in treatments and in tests            

10.4  Summary                                                                                                      

10.5  Questions and answers                                                                                 

10.6  Further reading

 

11  Immunological tolerance and regulation – why doesn’t the immune system attack ourselves?        

11.1  Immunological tolerance – what is it and why do we need it?                         

11.2  Self-tolerance in B cells                                                                                 

11.3  Self-tolerance in T lymphocytes – selecting for recognition of self-MHC but not self-antigen    

11.4  How do we maintain tolerance to self-antigens not expreseed in the thymus?               

11.5  Summary                                                                                                      

11.6  Questions and answers                                                                                 

11.7 Further reading                                    &nbp;                                                     

 

12  Autoimmune diseases                                                                                         

12.1  Autoimmune diseases occur when our immune systems attack our own bodies           

12.2  There are many different autoimmune diseases                                               

12.3  Immunological features of autoimmune diseases                                             

12.4  Both genetic and environmental factors contribute to the development of autoimmune disease 

12.5  How is immunological tolerance lost in autoimmune disease?                          

12.6  Summary                                                                                                      

12.7 Questions and answers                                                                                  

12.8 Further reading                                                                                              

 

13  Allergy and other hypersensitivities                                                                  

13.1  Introduction                                                                                                  

13.2  Type I hypersensitivity and allergy                                                                 

13.3  Allergies result in a variety of clinical symptoms                                              

13.4  Testing for allergy                                                                                         

13.5  Both genetics and the environment contribute to allergy                                  

13.6  Why have IgE in the first place?                                                                    

13.7  Treatment of allergy                                                                                      

13.8  Type II hypersensitivity                                                                                 

13.9  Type III hypersensitivity                                                                                

13.10 Differences between type II and type III hypersensitivity                               

13.11 Delayed hypersensitivity and contact hypersensitivity                             

13.12 Summary                                                                                                     

13.13 Questions and answers                                                                                

13.14 Further reading                                                                                            

 

14  AIDS                                                                                                                    

14.1  History and incidence of AIDS                                                                      

14.2  The human immunodeficiency virus                                                                

14.3  Clinical course of HIV infection                                                                     

14.4  Immunological events associated with HIV infection                                       

14.5  Chemotherapy can prolong the life of HIV-infected people                            

14.6  HIV has proven very difficult for vaccine development                                   

14.7  Summary     

14.8  Questions and answers                                                                                                                 

14.9 Further reading                                                                                             

 

15  Manipulating the immune system: transplantation and tumours                     

15.1  Introduction

15.2  Transplantation: from kidneys to faces                                                           

15.3  Using the immune system against tumours                                                      

15.4  Summary                                                                                                      

15.5 Questions and answers                                                                                 

15.6  Further reading                                                                                             

               

Glossary                                                                                                                      

Index                                                                                                                           

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Back Cover

'Brilliant combination of illustrations, content and question/answer sections. Good balance between theoretical immunology and case studies make it very useful for both lecturers and students.' - Professor Olivier Sparagano, Northumbria University

 

Understanding Immunology is a well-established introduction to this complex subject for readers with no previous exposure. It is aimed primarily at undergraduates in biological sciences, biomedical sciences and medicine. The selection and order of topic coverage is designed to instruct effectively, and a variety of boxed examples add depth and historical context for those readers wanting to go beyond the essentials.

 

The first part of the book (Chapters 1 to 11) takes students through the pathogenesis of infectious diseases and describes the molecules, cells and tissues of the immune system that provide protection against a wide variety of pathogens. It also describes how mankind has utilised the immune system, from the development of vaccines to the production of reagents for use in the clinic and laboratory. The final four chapters describe how the immune system operates in disease situations such as allergy, autoimmunity and transplantation.

 

This third edition is revised to cover the latest experimental and clinical changes in the subject, particularly those in the development of lymphocytes; the different types of CD4 helper T cells; the use of antibodies, including monoclonal antibodies, as experimental and clinical tools; and immunological tolerance.

 

Dr. Peter Wood is a Lecturer in the Faculty of Life Sciences at the University of Manchester. He has over 20 years of teaching experience, both in the UK and in the USA, and is widely published in the literature. His current research interest is the role of cytokines in the development of diabetes. 

 

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Author

Dr. Peter Wood is a Lecturer in the Faculty of Life Sciences at the University of Manchester. He has over 20 years of teaching experience, both in the UK and in the USA, and is widely published in the literature. His current research interest is the role of cytokines in the development of diabetes. 

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Reader Review(s)

"Nice book size, clear helpful diagrams and reasonable sized chapters, useful glossary. Helpful revision and updates in a fast changing field" - Peter Bentley, Head of Biology Department, City University

 

 "A very accessible text for students. The diagrams are clear and there are good Q&A sections" - Anne Humphreys, Senior Lecturer in Microbiology, Faculty of Science, Liverpool John Moores University

 


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