Concepts of Genetics with MasteringGenetics, Global Edition

Series
Pearson
Author
Michael A. Palladino / Charlotte A. Spencer / Michael R. Cummings / William S. Klug  
Publisher
Pearson
Cover
Softcover
Edition
11
Language
English
Pub.-date
January 2016
ISBN13
9781292077345
ISBN
1292077344
Related Titles


Textbook

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9781292077345
Concepts of Genetics with MasteringGenetics, Global Edition
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Description

For all introductory genetics courses.

This package includes MasteringGenetics.

Relevant, Conceptual, Cutting-edge

 

Concepts of Genetics, Eleventh Edition emphasizes the fundamental ideas of genetics, while exploring modern techniques and applications of genetic analysis. The best-selling text has a strong problem-solving approach, and this edition has been extensively updated with relevant, cutting-edge coverage of emerging topics in genetics. The accompanying MasteringGenetics online platform is updated with new tutorials and practice problems.

 

This package includes MasteringGenetics, an online homework, tutorial, and assessment program designed to work with this text to personalize learning and improve results. With a wide range of interactive, engaging, and assignable activities, students are encouraged to actively learn and retain tough course concepts.

 

My_Lab/Mastering is not a self-paced technology and should only be purchased when required by an instructor. Please be sure you have the correct ISBN and Course ID.  Instructors, contact your Pearson representative for more information.

 

Features

This title is a Pearson Global Edition. The Editorial team at Pearson has worked closely with educators around the world to include content which is especially relevant to students outside the United States.

 

Keep Your Course Current and Relevant

  • NEW!  Three new Special Topics in Modern Genetics mini-chapters explore cutting-edge topics, including updated content on Emerging Roles of RNA, Genetically Modified Foods, and Gene Therapy.
    • NEW!  For all Special Topics chapters, a series of questions have been added to send students back into the chapter to review key ideas or facilitate personal contemplations and group discussions.
    • NEW!  Assessment questions for Special Topics in Modern Genetics Chapters are now assignable in the MasteringGenetics item library, as reading questions.
  • NEW! Modern Approaches to Understanding Gene Function feature challenges students to understand how modern gene targeting approaches (such as the use of transgenic animals, knockout animals, and RNA interference) have dramatically advanced our understanding of gene function.  Each entry highlights representative experimental approaches, analyzes experimental data, and relates to a concept discussed in the chapter. Each feature includes questions for further analysis or discussion.
  • NEW! Evolving Concept of the Gene is a short feature, integrated in appropriate chapters, that highlights how scientists’ understanding of what a gene is has changed over time. Since we cannot see genes, we must infer just what this unit of heredity is, based on experimental findings.  By highlighting how scientists’ conceptualization of the gene has advanced over time, this feature helps students appreciate the process of discovery that has lead to an even more sophisticated understanding of hereditary information.
  • NEW! Chapter 24 Neurogenetics, previously entitled Behavior Genetics, has been completely reworked and redefined to reflect the wealth of information regarding the impact of genetics on the field of neurobiology, linking genetic analysis to brain function and brain disorders

Motivate Students to Develop and Practice Problem-solving Skills

  • Updated! MasteringGenetics is anonline homework and assessment program that guides students through complex topics in genetics, using in-depth tutorials that coach students to correct answers with hints and feedback specific to their misconceptions and errors. See “Personalize Learning with MasteringGenetics.”
  • Now Solve This Problems are integrated throughout each chapter to test student knowledge while learning chapter content. Exercises include a hint to guide students and a brief answer is provided in the appendix. One Now Solve This problem per chapter is now linked to related end of chapter problems to make it easier for professors to assign similar problems for homework.
  • Insights and Solutions sections strengthen students’ problem solving skills by showing step-by-step solutions and rationales for select problems.
  • Problems and Discussion Questions are found at the end of every chapter and most are assignable in Mastering. Extra Spicy Problems challenge students to solve complex problems, many based on data derived from primary genetics literature.
  • How Do We Know? questions appear as the first entry in the Problems and Discussion Questions and ask students to identify the experimental basis underlying important concepts and conclusions—that is, how we know what we know.

 

Emphasize the Fundamental Ideas of Genetics

  • Key Concepts are listed within chapter openers to help students focus on the core ideas of each chapter. The key concepts are revisited in greater detail in the end of chapter Summary Points.
  • NEW! Concepts Question is a new feature, found as the second question in the Problems and Discussion Questions that asks the student to review and comment on common aspects of the Key Concepts listed at the beginning of each chapter. This feature places added emphasis on the pedagogic approach of conceptual learning.

Engage Students in Active and Cooperative Learning

  • NEW!  Learning Catalytics is a “bring your own device” assessment and active classroom system that expands the possibilities for student engagement. Using Learning Catalytics, genetics instructors can deliver a wide range of auto-gradable or open-ended questions that test content knowledge and build critical thinking skills (see MasteringGenetics).
  • Updated! Case studies at the end of each chapter have been updated with new topics. Students can read and answer questions about a short scenario related to one of the chapter topics. The Case Studies link the coverage of formal genetic knowledge to everyday societal issues.
  • Exploring Genomics boxes help students apply genetics to modern techniques such as genomics, bioinformatics, and proteomics. These boxes illustrate how genomic studies have an impact on every aspect of genetics. Exercises provide thoughtful questions and direct students to related on line resources, allowing them to increase their awareness of genomics.
  • Genetics, Technology, and Society Essays reflect recent findings in genetics and their impact on society. It includes a section called Your Turn, which directs students to related resources of short readings and websites to support deeper investigation and discussion.

 

This package includes MasteringGenetics -- an online homework, tutorial, and assessment program designed to work with this text to personalize learning and improve results. With a wide range of interactive, engaging, and assignable activities, students are encouraged to actively learn and retain tough course concepts.

 

Personalize Learning with MasteringGenetics

  • Updated! MasteringGenetics is an online homework and assessment program that guides students through complex topics in genetics, using in-depth tutorials that coach students to correct answers with hints and feedback specific to their misconceptions and errors.
  • Approximately 90% of end-of-chapter questions are available for auto-graded homework assignments. To prepare students for the challenging problems that they are likely to see on exams, question types include sorting, labeling, entering numerical information, multiple choice, and fill-in-the-blank.
  • NEW! A library of 140 new Practice Problems offers more opportunities to assign high quality problems for student homework or practice. These questions appear only in MasteringGenetics, and solutions are not included in the Student Solutions Manual. These questions include targeted wrong answer feedback to help students learn from their mistakes.
  • NEW!  Learning Catalytics is a “bring your own device” assessment and active classroom system that expands the possibilities for student engagement.  Using Learning Catalytics, genetics instructors can deliver a wide range of auto-gradable or open-ended questions that test content knowledge and build critical thinking skills.
    • Eighteen different answer types provide great flexibility, including graphical, numerical, textual input, and more.
    • Instructors can create their own questions, draw from community content shared by colleagues, or access Pearson’s new library of question clusters that explore challenging topicsthrough a series of 2-5 questions that use a single scenario or set of data, build in difficulty, and require higher-level thinking.
  • NEW!  More tutorials have been added to the library, including 17 molecular model activities that allow students to manipulate genetic structures and answer questions.
  • NEW!  Assessment questions for Special Topics in Modern Genetics Chapters are now assignable in the MasteringGenetics item library,
  • More than 120 activities and in-depth tutorials, focused on key genetics concepts, reinforce problem-solving skills with hints and feedback specific to students’ misconceptions and errors. Tutorial topics include pedigree analysis, sex linkage, gene interactions, DNA replication, and more.
  • 24/7 Coaching in Solving Genetics Problems If students working on a tutorial get stuck, they can access hints to get back on track. If an incorrect answer is submitted, MasteringGenetics gives instant feedback specific to the error made, helping students overcome misconceptions and strengthen problem-solving skills.
  • Publisher Pre-built Assignments, curated by experienced MasteringGenetics users, consist of a broad range of high quality content focused on the key ideas of each chapter.  They make it easy to build assignments, and professors can use them as-is or customize them.

 

New to this Edition

Keep Your Course Current and Relevant

  • Three new Special Topics in Modern Genetics mini-chapters explore cutting-edge topics, including updated content on Emerging Roles of RNA, Genetically Modified Foods, and Gene Therapy.
    • For all Special Topics chapters, a series of questions have been added to send students back into the chapter to review key ideas or facilitate personal contemplations and group discussions.
    • Assessment questions for Special Topics in Modern Genetics Chapters are now assignable in the MasteringGenetics item library, as reading questions.
  • Modern Approaches to Understanding Gene Function feature challenges students to understand how modern gene targeting approaches (such as the use of transgenic animals, knockout animals, and RNA interference) have dramatically advanced our understanding of gene function.  Each entry highlights representative experimental approaches, analyzes experimental data, and relates to a concept discussed in the chapter. Each feature includes questions for further analysis or discussion.
  • Evolving Concept of the Gene is a short feature, integrated in appropriate chapters, that highlights how scientists’ understanding of what a gene is has changed over time. Since we cannot see genes, we must infer just what this unit of heredity is, based on experimental findings.  By highlighting how scientists’ conceptualization of the gene has advanced over time, this feature helps students appreciate the process of discovery that has lead to an even more sophisticated understanding of hereditary information.
  • Chapter 24 Neurogenetics, previously entitled Behavior Genetics, has been completely reworked and redefined to reflect the wealth of information regarding the impact of genetics on the field of neurobiology, linking genetic analysis to brain function and brain disorders.

 

Motivate Students to Develop and Practice Problem-solving Skills

  • Updated! MasteringGenetics is an online homework and assessment program that guides students through complex topics in genetics, using in-depth tutorials that coach students to correct answers with hints and feedback specific to their misconceptions and errors. See “Personalize Learning with MasteringGenetics.”

Emphasize the Fundamental Ideas of Genetics

  • Concepts Question is a new feature, found as the second question in the Problems and Discussion Questions that asks the student to review and comment on common aspects of the Key Concepts listed at the beginning of each chapter. This feature places added emphasis on the pedagogic approach of conceptual learning.

Engage Students in Active and Cooperative Learning

  • Learning Catalytics is a “bring your own device” assessment and active classroom system that expands the possibilities for student engagement. Using Learning Catalytics, genetics instructors can deliver a wide range of auto-gradable or open-ended questions that test content knowledge and build critical thinking skills (see MasteringGenetics).
  • Updated! Case studies at the end of each chapter have been updated with new topics. Students can read and answer questions about a short scenario related to one of the chapter topics. The Case Studies link the coverage of formal genetic knowledge to everyday societal issues.

 

Chapter Content Updates:

Ch. 1: Introduction to Genetics

  • New chapter introduction vignette emphasizing translational medicine.

Ch. 3: Mendelian Genetics

  • New Understanding Gene Function section: Identifying Mendel’s Gene for Regulating White Flower Color in Peas
  • New end of chapter problems based on Migaloo, the albino hump-backed whale.

Ch. 7: Sex Determination and Sex Chromosomes

  • New coverage on paternal age effects (PAEs) in humans.
  • New Understanding Gene Function section: Drosophila Sxl Gene Induces Female Development.

Ch. 8: Chromosome Mutations: Variation in Number and Arrangement

  • Updated coverage of fragile X syndrome.
  • New Understanding Gene Function section: Mouse Models of Down Syndrome.

Ch. 9: Extranuclear Inheritance

  • New coverage on mitochondrial swapping and the prevention of mtDNA-based disorders.

Ch. 11: DNA Replication and Recombination

  • Updated coverage of DNA Pol III holoenzyme.
  • Revised figures involving DNA synthesis.
  • New coverage of the initiation of bacterial DNA synthesis.
  • New coverage of homologous recombination and gene conversion.
  • New coverage of replication of telomeric DNA.
  • New Understanding Gene Function section: Lethal Knockouts of DNA Ligase Genes.

Ch. 12: DNA Organization in Chromosomes

  • New coverage of kinetechore structure and function.

Ch. 14: Translation and Proteins

  • Revision of all ribosome figures.

Ch. 15: Gene Mutation, DNA Repair, and Transposition

  • New data on spontaneous mutation rates in humans.
  • Reorganization and updates for mutation classification.
  • Updated coverage of Xeroderma Pigmentosum and DNA repair mechanisms.
  • New Understanding Gene Function section: Transposon-Mediated Mutations Reveal Genes Involved in Colorectal Cancer

Ch. 16: Regulation of Gene Expression in Prokaryotes

  • Updated coverage of gene regulation by riboswitches.

Ch. 17: Regulation of Gene Expression in Eukaryotes

  • Expanded coverage of chromatin modifications
  • Introduction of Weintraub & Groudine’s experiments involving chromatin structure and transcription regulation.
  • Updated coverage of promoter and enhancer structures and functions.
  • Updated coverage of the mechanisms of transcription activation and repression.
  • Updated section on RNA silencing.
  • New section: ENCODE Data Are Transforming Our Concepts of Eukaryotic Gene Regulation.
  • New Understanding Gene Function section: MicroRNAs Regulate Ovulation in Female Mice.

Ch. 18: Developmental Genetics

  • New Section: Master Switch Genes, including four new figures.
  • New Understanding Gene Function section: Single-Gene Signaling Mechanism Reveals Secrets to Head Regeneration in Planaria.

Ch. 19: Cancer and Regulation of the Cell Cycle

  • New coverage of the progressive nature of colorectal cancers.
  • Revised and updated coverage of driver and passenger mutations.
  • Expanded coverage of the role of viruses in human cancers.

Ch. 20: Recombinant DNA Technology

  • Expanded coverage and new figure on third-generation DNA sequencing.
  • New section on Gene Targeting that includes content and figures on gene knockout animals, conditional knockouts, and transgenic animals.

Ch. 21: Genomics, Bioinformatics, and Proteomics

  • Updated coverage of the Human Microbiome Project.
  • New content introducing exome sequencing.
  • Updated coverage of personal genome projects.
  • Revised and expanded coverage of the Encyclopedia of DNA Elements (ENCODE) Project.
  • New content and figure covering chromatin-immunoprecipitation (ChIP) and ChIP-sequencing (ChIP-Seq).
  • New Case Study discussing the microbiome as a risk factor for disease.

Ch. 22: Applications and Ethics of Genetic Engineering and Biotechnology

  • New section and figure on Synthetic Biology for Bioengineering Applications.
  • New coverage and figure on deducing fetal genome sequences from maternal blood.
  • Updated coverage of prenatal genetic testing.
  • Updated coverage of the minimal genome.
  • New coverage involving genetic analysis by sequencing individual genomes for clinical purposes and single-cell sequencing.
  • Revised ethics section to include additional discussion on the analysis of whole genome sequences, preconception testing, DNA patents, and destiny predictions.
  • Major revision of PDQ content and additional new questions.
  • New GTS essay: Privacy and Anonymity of Genomic Data.
  • New Case Study on Genetically Modified Bacteria for Cancer Treatment.

Ch. 23: Quantitative Genetics and Multifactorial Traits

  • Updated coverage of Quantitative Trait Loci (QTL) in studying multifactorial phenotypes.

Ch. 24: Neurogenetics

  • Conversion of the Behavior Genetics chapter to one entitled Neurogenetics, with emphasis on molecular events in the brain and nervous system related to behavior.  Includes ten new figures and three 3 new tables.
  • New Understanding Gene Function section: RbAp48 and a Potential Molecular Mechanism for Age-Related Memory Loss

Ch. 25: Population and Evolutionary Genetics

  • New coverage on macroevolution and the rate of speciation.
  • Revision of the discussion of the molecular clock.
  • Two new sections: Complex Organization of Our Genome; and Our Genome is a Mosaic.

Special Topics Chapter 1: Epigenetics

  • New section: The Role of  RNA in Epigenetics

Special Topics Chapter 2: Emerging Roles of RNA

  • New chapter on the newly discovered emerging roles of RNA--focuses on the diverse functions of RNAs with an emphasis on noncoding RNA.

Special Topics Chapter 3: Forensics

  • New coverage describing how DNA can be inadvertently transferred to a crime scene, leading to false arrests
  • New coverage of DNA phenotyping

Special Topics Chapter 4: Personalized Medicine

  • New coverage on personal genomics and cancer, including new story of one person’s successful experience using ‘omics’ profiling to select a personalized cancer treatment.
  • Updated coverage of personalized medicine and disease diagnostics.
  • Updated coverage of recent studies using ‘omics’ profiles to predict and  monitor disease states.

Special Topics Chapter 5: Genetically Modified Foods

  • New chapter on Genetically Modified Foods – the genetic technology behind them, the promises, debates and controversies.

Special Topics Chapter 6: Gene Therapy

  • New chapter on the modern aspects of gene therapy—provides up-to-date applications of gene therapy in humans.

 

This package includes MasteringGenetics -- an online homework, tutorial, and assessment program designed to work with this text to personalize learning and improve results. With a wide range of interactive, engaging, and assignable activities, students are encouraged to actively learn and retain tough course concepts.

 

Personalize Learning with MasteringGenetics

  • Updated! MasteringGenetics is an online homework and assessment program that guides students through complex topics in genetics, using in-depth tutorials that coach students to correct answers with hints and feedback specific to their misconceptions and errors.
  • Approximately 90% of end-of-chapter questions are available for auto-graded homework assignments. To prepare students for the challenging problems that they are likely to see on exams, question types include sorting, labeling, entering numerical information, multiple choice, and fill-in-the-blank.
  • NEW! A library of 140 new Practice Problems offers more opportunities to assign high quality problems for student homework or practice. These questions appear only in MasteringGenetics, and solutions are not included in the Student Solutions Manual. These questions include targeted wrong answer feedback to help students learn from their mistakes.
  • NEW!  Learning Catalytics is a “bring your own device” assessment and active classroom system that expands the possibilities for student engagement.  Using Learning Catalytics, genetics instructors can deliver a wide range of auto-gradable or open-ended questions that test content knowledge and build critical thinking skills.
    • Eighteen different answer types provide great flexibility, including graphical, numerical, textual input, and more.
    • Instructors can create their own questions, draw from community content shared by colleagues, or access Pearson’s new library of question clusters that explore challenging topicsthrough a series of 2-5 questions that use a single scenario or set of data, build in difficulty, and require higher-level thinking.
  • NEW!  More tutorials have been added to the library, including 17 molecular model activities that allow students to manipulate genetic structures and answer questions.
  • NEW!  Assessment questions for Special Topics in Modern Genetics Chapters are now assignable in the MasteringGenetics item library,
  • More than 120 activities and in-depth tutorials, focused on key genetics concepts, reinforce problem-solving skills with hints and feedback specific to students’ misconceptions and errors. Tutorial topics include pedigree analysis, sex linkage, gene interactions, DNA replication, and more.
  • 24/7 Coaching in Solving Genetics Problems If students working on a tutorial get stuck, they can access hints to get back on track. If an incorrect answer is submitted, MasteringGenetics gives instant feedback specific to the error made, helping students overcome misconceptions and strengthen problem-solving skills.
  • Publisher Pre-built Assignments, curated by experienced MasteringGenetics users, consist of a broad range of high quality content focused on the key ideas of each chapter.  They make it easy to build assignments, and professors can use them as-is or customize them.

 

Table of Contents

Part One

Genes, Chromosomes, and Heredity
1 Introduction to Genetics
2 Mitosis and Meiosis
3 Mendelian Genetics
4 Extensions of Mendelian Genetics
5 Chromosome Mapping in Eukaryotes
6 Genetic Analysis and Mapping in Bacteria and Bacteriophages
7 Sex Determination and Sex Chromosomes
8 Chromosome Mutations: Variation in Number and Arrangement
9 Extranuclear Inheritance


Part Two
DNA: Structure, Replication, and Variation
10 DNA Structure and Analysis
11 DNA Replication and Recombination
12 DNA Organization in Chromosomes


Part Three
Gene Expression, Regulation, and Development
13 The Genetic Code and Transcription
14 Translation and Proteins
15 Gene Mutation, DNA Repair, and Transposition
16 Regulation of Gene Expression in Prokaryotes
17 Regulation of Gene Expression in Eukaryotes
18 Developmental Genetics
19 Cancer and Regulation of the Cell Cycle


Part Four
Genomics
20 Recombinant DNA Technology
21 Genomics, Bioinformatics, and Proteomics
22 Applications and Ethics of Genetic Engineering  and Biotechnology


Part Five
Genetics of Organisms and Populations
23 Quantitative Genetics and Multifactorial Traits
24 Neurogenetics
25 Population and Evolutionary Genetics


Special Topics in Modern Genetics
1 Epigenetics
2 Emerging Roles of RNA
3 DNA Forensics
4 Genomics and Personalized Medicine
5 Genetically Modified Foods
6 Gene Therapy


Appendix A Selected Readings
Appendix B Answers
Glossary
Credits