Concepts of Genetics plus Pearson Modified MasteringGenetics with Pearson eText, Global Edition

Series
Pearson
Author
William S. Klug / Michael R. Cummings / Charlotte A. Spencer / Michael A. Palladino / Darrell Killian  
Publisher
Pearson
Cover
Softcover
Edition
12
Language
English
Pub.-date
June 2019
ISBN13
9781292265544
ISBN
129226554X


Product detail

Product Price CHF Available  
9781292265544
Concepts of Genetics plus Pearson Modified MasteringGenetics with Pearson eText, Global Edition
129.70 not defined

Free evaluation copy for lecturers


Description

For all introductory genetics courses.

This package includes Modified Mastering Genetics.

 

Teach students core genetics concepts and applications

Concepts of Genetics emphasizes the fundamental ideas of genetics, while exploring modern techniques and applications of genetic analysis. This best-selling text continues to provide understandable explanations of complex, analytical topics and recognizes the importance of teaching students how to become effective problem solvers.

 

The 12th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas and the study of posttranscriptional gene regulation in eukaryotes. An expanded emphasis on ethical considerations that genetics is bringing into everyday life is addressed in Genetics, Ethics, and Society and Case Study features.

 

Reach every student by pairing this text with Modified Mastering Genetics

Mastering is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools developed to engage students and emulate the office-hour experience, Mastering personalizes learning and improves results for each student.

 

Modified Mastering Genetics should only be purchased when required by an instructor. Please be sure you have the correct ISBN and Course ID. Instructors, contact your Pearson representative for more information.

Features

This title is a Pearson Global Edition. The Editorial team at Pearson has worked closely with educators around the world to include content which is especially relevant to students outside the United States.

 

Keep Your Course Current and Relevant

  • Two new Special Topics in Modern Genetics mini-chapters explore cutting-edge topics, including CRISPR-Cas and Genomic Editing and Advances in Neurogenetics: The Study of Huntington Disease.
    • All Special Topics chapters include a series of questions that help students review key ideas or facilitate personal contemplations and group discussions.
    • Assessment questions for Special Topics in Modern Genetics Chapters are assignable in Modified Mastering Genetics.
  • Reorganized and expanded coverage of gene regulation in eukaryotes reflects recent discoveries that reveal how RNA in many forms plays critical roles in the regulation of eukaryotic gene activity.  A single chapter on this topic in previous editions has been expanded to three:  Transcriptional Regulation in Eukaryotes (Chapter 17), Posttranscriptional Regulation in Eukaryotes (Chapter 18), and Epigenetics (Chapter 19).
  • An increased emphasis on ethical considerations helps students think through ethical aspects of genetics-related issues.  Essays that used to be known as Genetics, Technology, and Society have been replaced or revised as Genetics, Ethics, and Society.  In addition, each chapter ends with a Case Study, each of which raises ethical questions.
  • Modern Approaches to Understanding Gene Function feature challenges students to understand how modern gene targeting approaches (such as the use of transgenic animals, knockout animals, and RNA interference) have dramatically advanced our understanding of gene function. Each entry highlights representative experimental approaches, analyzes experimental data, and relates to a concept discussed in the chapter. Each feature includes questions for further analysis or discussion.

Motivate Students to Develop and Practice Problem-solving Skills

  • Updated! Modified Mastering Genetics is an online homework and assessment program that guides students through complex topics in genetics, using in-depth tutorials that coach students to correct answers with hints and feedback specific to their misconceptions and errors. See “Personalize Learning with Modified Mastering Genetics.”
  • Now Solve This Problems are integrated throughout each chapter to test student knowledge while learning chapter content. Exercises include a hint to guide students and a brief answer is provided in the appendix. One Now Solve This problem per chapter is linked to related end of chapter problems to make it easier for professors to assign similar problems for homework.
  • Insights and Solutions sections strengthen students’ problem solving skills by showing step-by-step solutions and rationales for select problems.
  • Problems and Discussion Questions are found at the end of every chapter and most are assignable in Modified Mastering Genetics.
  • Extra Spicy Problems challenge students to solve complex problems, many based on data derived from primary genetics literature.
  • How Do We Know? questions appear as the first entry in the Problems and Discussion Questions and ask students to identify the experimental basis underlying important concepts and conclusions—that is, how we know what we know. Students are asked to review numerous findings discussed in the chapter and to summarize the process of discovery that was involved.  

Emphasize the Fundamental Ideas of Genetics

  • A Concept Question, found as the second question in the Problems and Discussion Questions, asks the student to review and comment on common aspects of the Key Concepts listed at the beginning of each chapter. This feature places added emphasis on the pedagogic approach of conceptual learning.
  • Evolving Concept of the Gene is a short feature, integrated in appropriate chapters, that highlights how scientists’ understanding of what a gene is has changed over time. Since we cannot see genes, we must infer just what this unit of heredity is, based on experimental findings. By highlighting how scientists’ conceptualization of the gene has advanced over time, this feature helps students appreciate the process of discovery that has lead to an even more sophisticated understanding of hereditary information.

Engage Students in Active and Cooperative Learning

  • NEW! Genetics, Ethics, and Society essays provide a synopsis of an ethical issue related to a current finding in genetics that impacts directly on society today. It includes a section called Your Turn, which directs students to related resources of short readings and websites to support deeper investigation and discussion of the main topic of each essay.
  • Case studies at the end of each chapter have been updated with new topics. Students can read and answer questions about a short scenario related to one of the chapter topics. The Case Studies link the coverage of formal genetic knowledge to everyday societal issues, and they include ethical considerations.
  • Exploring Genomics boxes help students apply genetics to modern techniques such as genomics, bioinformatics, and proteomics. These boxes illustrate how genomic studies have an impact on every aspect of genetics. Exercises provide thoughtful questions and direct students to related online resources, allowing them to increase their awareness of genomics.

 

 

This package includes Modified Mastering Genetics, the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools and a flexible platform, Mastering personalizes the learning experience and often improves results for each student.

  • NEW! Dynamic Study Modules (DSMs) help students study effectively on their own by continuously assessing their performance in real time and adapting to their level of understanding. Students complete a set of questions with a unique answer format that also asks them to indicate their confidence level in their answer. Questions repeat until the student can answer them all correctly and confidently.  These are available as graded assignments prior to class or as self-study tools for students. They are accessible on smartphones, tablets, and computers. Instructors can delete questions from Dynamic Study Modules to better fit their course.
  • NEW! Tutorials have been added to the library on topics like CRISPR–Cas, to help students master important and challenging concepts.
  • A library of 104 Practice Problems offers more opportunities to assign high quality problems for student homework or practice. These questions appear only in Modified Mastering Genetics and include targeted wrong-answer feedback to help students learn from their mistakes.
  • More than 120 activities and in-depth tutorials, focused on key genetics concepts, reinforce problem-solving skills with hints and feedback specific to students’ misconceptions and errors. Tutorial topics include pedigree analysis, sex linkage, gene interactions, DNA replication, and more.
  • Approximately 90% of end-of-chapter questions are available for auto-graded homework assignments. To prepare students for the challenging problems that they are likely to see on exams, question types include sorting, labeling, entering numerical information, multiple choice, and fill-in-the-blank.
  • 24/7 Coaching in Solving Genetics Problems give students access hints to get back on track at the moment when they get stuck. If an incorrect answer is submitted, Modified Mastering Genetics gives instant feedback specific to the error made, helping students overcome misconceptions and strengthen problem-solving skills.
    • Publisher Pre-built Assignments, curated by experienced Modified Mastering Genetics users, consist of a broad range of high quality content focused on the key ideas of each chapter.  They make it easy to build assignments, and professors can use them as-is or customize them.
  • Assessment questions for Special Topics in Modern Genetics Chapters are assignable in the Modified Mastering Genetics item library,
  • Learning Catalytics helps generate class discussion, customize lectures, and promote peer-to-peer learning with real-time analytics. Learning Catalytics acts as a student response tool that uses students’ smartphones, tablets, or laptops to engage them in more interactive tasks and thinking.
    • Help your students develop critical thinking skills.
    • Monitor responses to find out where your students are struggling.
    • Rely on real-time data to adjust your teaching strategy.
    • Automatically group students for discussion, teamwork, and peer-to-peer learning.
    • Upload a full PowerPoint® deck to easily create slide questions.

New to this Edition

About the Book

 

Keep Your Course Current and Relevant

  • Two new Special Topics in Modern Genetics mini-chapters explore cutting-edge topics, including CRISPR-Cas and Genomic Editing and Advances in Neurogenetics: The Study of Huntington Disease.
    • All Special Topics chapters include a series of questions that help students review key ideas or facilitate personal contemplations and group discussions.
    • Assessment questions for Special Topics in Modern Genetics Chapters are assignable in Modified Mastering Genetics.
  • Reorganized and expanded coverage of gene regulation in eukaryotes reflects recent discoveries that reveal RNA in many forms play critical roles in the regulation of eukaryotic gene activity.  A single chapter on this topic in previous editions has been expanded to three:  Transcriptional Regulation in Eukaryotes (Chapter 17), Posttranscriptional Regulation in Eukaryotes (Chapter 18), and Epigenetics (Chapter 19).
  • An increased emphasis on ethical considerations helps students think through ethical aspects of genetics-related issues.  Essays that used to be known as Genetics, Technology, and Society have been replaced or revised as Genetics, Ethics, and Society.  In addition, each chapter ends with a Case Study, each of which raises ethical questions.

Motivate Students to Develop and Practice Problem-solving Skills

  • Updated! Modified Mastering Genetics is an online homework and assessment program that guides students through complex topics in genetics, using in-depth tutorials that coach students to correct answers with hints and feedback specific to their misconceptions and errors. See “Personalize Learning with Modified Mastering Genetics.”

Engage Students in Active and Cooperative Learning

  • Genetics, Ethics, and Society essays provide a synopsis of an ethical issue related to a current finding in genetics that impacts directly on society today. It includes a section called Your Turn, which directs students to related resources of short readings and websites to support deeper investigation and discussion of the main topic of each essay.
  • Case studies at the end of each chapter have been updated with new topics. Students can read and answer questions about a short scenario related to one of the chapter topics. The Case Studies link the coverage of formal genetic knowledge to everyday societal issues, and they include ethical considerations.

 

Chapter Content Updates:

 

Chapter 1: Introduction to Genetics

  • New introductory vignette that discusses the discovery and applications of the genome-editing CRISPR-Cas system
  • Updated section called: We Live in the Age of Genetics

Chapter 7: Sex Determination and Sex Chromosomes

  • Updated content on the XIST gene product as a long noncoding RNA
  • New insights about a novel gene involved in temperature sensitive differentiation of snapping turtles and lizards, as well as the impact of climate change on sex, sex reversal, and sex ratios

Chapter 9: Extranuclear Inheritance

  • Updated information on mtDNA disorders and nuclear DNA mismatches

Chapter 11: DNA Replication and Recombination

  • New coverage of the role of telomeres in disease, aging, and cancer
  • New and expanded coverage of telomeres and chromosome stability, explaining how telomeres protect chromosome ends

Chapter 13: The Genetic Code and Transcription

  • New coverage on transcription termination in bacteria
  • New section entitled Why Do Introns Exist?
  • Updated coverage on RNA editing

Chapter 14: Translation and Proteins

  • New coverage of eukaryotic closed-loop translation, including a new figure
  • Revised coverage of Beadle and Tatum’s classic experiments
  • Expanded coverage on the posttranslational modifications of proteins
  • New coverage of the insights gleaned from the crystal structure of the human 80S ribosome

Chapter 15: Gene Mutation, DNA Repair, and Transposons

  • New and revised coverage on transposons, focusing on the mechanisms of transposition by both retrotransposons and DNA transposons, as well as a discussion of how transposition creates mutations;two new tables and five new figures are included
  • Reorganization of mutation classification section with table summaries
  • New and expanded coverage of human germ-line and somatic mutation rates

NEW! Chapter 17: Transcriptional Regulation in Eukaryotes

  • Revised chapter organization focuses specifically on transcriptional regulation
  • Revised coverage of regulation of the GAL gene system in yeast with an updated figure
  • New coverage on genetic boundary elements called insulators

NEW! Chapter 18: Posttranscriptional Regulation in Eukaryotes

  • New chapter that greatly expands upon previous coverage of posttranscriptional gene regulation in eukaryotes
  • Revised and expanded coverage of alternative splicing and its relevance to human disease
  • Expanded coverage on RNA stability and decay with a new figure
  • Updated coverage of noncoding RNAs that regulate gene expression with a new figure
  • Enriched coverage of ubiquitin-mediated protein degradation with a new figure

NEW! Chapter 19: Epigenetic Regulation in Eukaryotes

  • New chapter on Epigenetics, including coverage of epigenetics and cancer, transmission of epigenetic traits across generations, and the role of epigenetics in behavior
  • New coverage on the recently discovered phenomenon of monoallelic expression of autosomal genes
  • Updated coverage of epigenome projects

Chapter 20: Recombinant DNA Technology

  • Increased emphasis on the importance of whole-genome sequencing approaches
  • New coverage of CRISPR-Cas as a gene editing approach including a new figure
  • Updated content on next-generation and third-generation sequencing

Chapter 21: Genomic Analysis

  • Increased emphasis on the integration of genomics, bioinformatics, and proteomics approaches to analyzing genomes and understanding genome function
  • A new section entitled Genomic Analysis Before Modern Sequencing Methods, which briefly summarizes approaches to mapping and identifying genes prior to modern sequencing
  • Reorganized and revised content on the Human Genome Project.  Updated content on personal genome projects and new content on diploid genomes and mosaicism and the pangenome to emphasize human genetic variations
  • New coverage of the Human Microbiome Project including a new figure displaying microbiome results of patients with different human disease conditions
  • New coverage of in situ RNA sequencing

Chapter 22: Applications of Genetic Engineering and Biotechnology

  • Updated content on biopharmaceutical products including newly approved recombinant proteins, DNA vaccine trials to immunize against Zika virus, genetically modified organisms, and gene drive in mosquitoes to control spread of Zika
  • New coverage of genes essential for life and how synthetic genomics is being applied to elucidate them; clarification of prognostic and diagnostic genetics tests and the relative value of each for genetic analysis
  • New content on DNA and RNA sequencing
  • New section entitled Screening the Genome for Genes or Mutations You Want, which discusses how scientists can look at genetic variation that confers beneficial phenotypes
  • New section entitled Genetic Analysis by Personal Genomics Can Include Sequencing of DNA and RNA that expands coverage of personal genome projects and new approaches for single-cell genetic analysis of DNA and RNA

 

Chapter 23: Developmental Genetics

  • New section entitled Epigenetic Regulation of Development
  • New coverage of DNA methylation and progressive restriction of developmental potential
  • Expanded coverage of binary switch genes and regulatory networks

Chapter 24: Cancer Genetics

  • Extended coverage of environmental agents that contribute to human cancers), including more information about both natural and human-made carcinogens
  • New section entitled Tobacco Smoke and Cancer explaining how a well-studied carcinogen induces a wide range of genetic effects that may lead to mutations and cancer
  • New section entitled Cancer Therapies and Cancer Cell Biology, describing the mechanisms of chemotherapies and radiotherapies as they relate to cancer cell proliferation, DNA repair, and apoptosis

Chapter 25: Quantitative Genetics and Multifactorial Traits

  • Updated coverage on quantitative trait loci (QTLs)
  • Revised and expanded section eQTLs and Gene Expression

Chapter 26: Population and Evolutionary Genetics

  • New coverage on vertebrate evolution
  • New coverage of phylogenetic trees
  • Updated coverage on the origins of the human genome
  • New section entitled Genotype and Allele Frequency Changes
  • New coverage on pre-and post-zygotic isolating mechanisms

NEW! Special Topics 1: CRISPR-Cas and Genome Editing

  • New chapter on a powerful genome editing tool called CRISPR-Cas
  • Provides up to date coverage on CRISPR-Cas applications, the patenting of this technology, and the ethical concerns of human genome editing

Special Topics 2: DNA Forensics

  • New section on the still controversial DNA Phenotyping Method, including new explanations of how law enforcement agencies currently use DNA phenotyping

Special Topics 3: Genomics and Precision Medicine

  • New section entitled Precision Oncology, including descriptions of two targeted cancer immunotherapies: adoptive cell transfer and engineered T-cell therapies
  • Updated pharmacogenomics coverage, including a description of new trends in pre-emptive gene screening for pharmacogenomic variants as well as the pGEN4Kids program, a pre-emptive gene screening program that integrates DNA analysis data into patient electronic health records

Special Topics 4: Genetically Modified Foods

  • New section entitled Gene Editing and Genetically Modified Foods describing how scientists are using the new techniques of gene editing (including ZFN, TALENS, and CRISPR-Cas) to create GM plants and animals, and how these methods are changing the way in which GM foods are being regulated
  • A new box entitled The New CRISPR Mushroom describing the development and regulatory approval of the first CRISPR-created GM food to be approved for human consumption

Special Topics 5: Gene Therapy

  • Updated current data on gene therapy trials underway
  • Reordered chapter content to highlight emergence of CRISPR-Cas in a new section on Gene Editing
  • Substantially expanded content on CRISPR-Cas including a brief summary of some of the most promising trials in humans and animals to date
  • Incorporation of antisense RNA and RNA interference into a new section entitled RNA-based Therapeutics, including updated trials involving spinal muscular atrophy
  • Updated content on roles for stem cells in gene therapy
  • New content on combining gene editing with immunotherapy
  • New ethical discussions on CRISPR-Cas and germ-line and embryo editing

NEW! Special Topics  6: Advances in Neurogenetics: The Study of Huntington Disease (HD)

  • New chapter that surveys the study of HD commencing around 1970 up to the current time
  • Coverage of the genetic basis and expression of HD, the mapping and isolation of the gene responsible for the disorder, the mutant gene product, molecular and cellular alterations caused by the mutation, transgenic animal models of HD, cellular and molecular approaches to therapy, and a comparison of HD to other inherited neurodegenerative disorders

 

This package includes Modified Mastering Genetics, the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools and a flexible platform, Mastering personalizes the learning experience and often improves results for each student.

 

  • Dynamic Study Modules (DSMs) help students study effectively on their own by continuously assessing their performance in real time and adapting to their level of understanding. Students complete a set of questions with a unique answer format that also asks them to indicate their confidence level in their answer. Questions repeat until the student can answer them all correctly and confidently.  These are available as graded assignments prior to class or as self-study tools for students. They are accessible on smartphones, tablets, and computers. Instructors can remove questions from Dynamic Study Modules to better fit their course.
  • Tutorials have been added to the library on topics like CRISPR–Cas, to help students master important and challenging concepts.

 

Table of Contents

Part One--Genes, Chromosomes, and Heredity

1 Introduction to Genetics

2 Mitosis and Meiosis

3 Mendelian Genetics

4 Extensions of Mendelian Genetics

5 Chromosome Mapping in Eukaryotes

6 Genetic Analysis and Mapping in Bacteria and Bacteriophages

7 Sex Determination and Sex Chromosomes

8 Chromosome Mutations: Variation in Number and Arrangement

9 Extranuclear Inheritance

 

Part Two--DNA: Structure, Replication, and Organization

10 DNA Structure and Analysis

11 DNA Replication and Recombination

12 DNA Organization in Chromosomes

 

Part Three--Gene Expression and Its Regulation

13 The Genetic Code and Transcription

14 Translation and Proteins

15 Gene Mutation, DNA Repair, and Transposition

16 Regulation of Gene Expression in Bacteria

17 Transcriptional Regulation in Eukaryotes

18 Post-transcriptional Regulation in Eukaryotes

19 Epigenetic Regulation in Eukaryotes

 

Part Four--Genomics

20 Recombinant DNA Technology

21 Genomic Analysis

22 Applications of Genetic Engineering and Biotechnology

 

Part Five--Genetics of Organisms and Populations

23 Developmental Genetics

24 Cancer Genetics

25 Quantitative Genetics and Multifactorial Traits

26 Population and Evolutionary Genetics

 

Special Topics in Modern Genetics

ST1 CRISPR and Genomic Editing

ST2 DNA Forensics

ST3 Genomics and Precision Medicine

ST4 Genetically Modified Foods

ST5 Gene Therapy

ST6 Advances in Neurogenetics: The Study of Huntington Disease

Appendix A Selected Readings

Appendix B Answers to Selected Problems